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Home > Antibiotics > Generic Azithromycin (type may vary) > Azithromycin Tablets for Dogs and Cats, 250mg, 18 Tablets
Compounding is often thought of as the process of combining or mixing drugs to create a medicine tailored to the needs of an individual patient.
Azithromycin is a macrolide antibiotic that can be prescribed for infections. Azithromycin Comounded capsule is a long blue and white capsule made especially for your pet.
For dogs, the usual dose is 2.5 to 5 mg per kilogram 5 to 10 mg/kg orally once daily for 7 days.
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In cats, the usual dose is 2.5 to 7.5 mg per kilogram 5 to 15 mg/kg orally every 12 to 24 hours for up to 7 days.
The duration of the medication depends on the condition being treated, the response to the medication and the development of side effects.
Be sure to finish the prescription unless specifically instructed to do so by your veterinarian. Even if your pet feels better, the full course of treatment must be completed before a relapse occurs.
Tap the bottle to release the powder. Add the indicated amount of water to the bottle. After mixing, use within 10 days. Discard the entire dose afterwards. After mixing, store the suspension at 41 to 86 degrees F. A large bottle gives extra room to shake.
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For liquids, shake well before measuring the dose accurately. If the suspension is used, it should be given on an empty stomach. Administer the medication as directed by your veterinarian. This medicine is usually given once or twice a day. Read and follow the label carefully. Give the exact amount prescribed and as often as prescribed. Missed doses reduce the effectiveness of the treatment. Administer this medicine as long as your veterinarian prescribes. Complete the entire treatment process. It is best to give the medicine at the same time every day.
Azithromycin should not be used in animals with known allergy or sensitivity to other macrolide antibiotics. In addition, it should be used with caution if liver disease is common. Gastrointestinal side effects may include vomiting, diarrhea, or abdominal pain. Angioedema and cholestatic jaundice have been rarely reported in treated humans. Arrhythmias, including ventricular tachycardia, may be induced by azithromycin. Renal dysfunction, including interstitial nephritis and acute renal failure, may occur after azithromycin therapy and liver function may be impaired.
Azithromycin may increase the serum concentration of digoxin. When ergotamine or dihydroergotamine is co-administered with azithromycin, toxicity may occur. Azithromycin reduces the clearance of triazolam and therefore increases its pharmacological effect Pimozide should not be used in patients receiving azithromycin and vice versa, it can cause death Animals treated with Cisapride should not take azithromycin or other macrolide antibiotics drugs metabolized by cytochrome P450, e.g. Serum levels of carbamazepine, terfenadine, cyclosporine, hexobarbital, and phenytoin are increased by azithromycin Oral antacids decrease azithromycin absorption.
Azithromycin for injection is indicated for the treatment of patients with infections caused by susceptible strains of the microorganisms named in the following conditions. As recommended dosages, duration of therapy, and appropriate patient populations vary among these infections, see Dosage and Administration for dosage recommendations.
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Patients requiring initial intravenous therapy. If anaerobic microorganisms are suspected of causing the infection, antibiotics with anaerobic activity should be given together with injectable azithromycin.
Injectable azithromycin should be added to oral azithromycin as needed. (See Dosage and Administration.)
Appropriate culture and susceptibility testing should be performed prior to treatment to determine the causative organism and its susceptibility to azithromycin. Treatment with azithromycin can be started before the results of these tests are known; when results are available, antibiotic treatment should be adjusted accordingly.
To reduce the development of drug-resistant bacteria and to maintain the effectiveness of azithromycin and other antibacterial drugs, azithromycin should only be used to treat or prevent infections caused by susceptible bacteria. When culture and susceptibility data are available, they should be considered when choosing or changing antibiotic therapy. In the absence of such data, local epidemiology and susceptibility patterns may assist in the selection of empiric treatment.
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Serious allergic reactions including angioedema, anaphylaxis, and skin reactions including Stevens Johnson syndrome and toxic epidermal necrolysis have been reported rarely in patients treated with azithromycin. Although rare, deaths have been reported. (See Contraindications.) Despite initially successful symptomatic treatment of allergic symptoms, when symptomatic treatment was discontinued, allergic symptoms recurred shortly thereafter in some patients without further exposure to azithromycin. These patients required prolonged observation and symptomatic treatment. The relationship of these events to the prolonged tissue half-life of azithromycin and subsequent prolonged antigen exposure is currently unknown.
If an allergic reaction occurs, stop using the drug and start appropriate treatment. Physicians should be aware that allergy symptoms may recur when symptomatic treatment is discontinued.
Associated diarrhea (CDAD) has been reported with the use of almost all antibacterial drugs, including injectable azithromycin, and the diarrhea can range from mild to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon, causing overgrowth
C. difficile causes increased morbidity and mortality, as these infections may be refractory to antibiotic therapy and require colonic resection. CDAD should be considered in all patients who develop diarrhea after antibiotic use. A careful medical history is essential, as CDAD has been reported to occur more than two months after the administration of antibiotics.
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Because azithromycin is eliminated primarily by the liver, caution should be exercised when azithromycin is administered to patients with hepatic impairment. Because of limited data in subjects with GFR <10 ml/min, caution should be exercised when prescribing azithromycin in these patients. (See clinical pharmacology, special groups, renal impairment).
Azithromycin for injection should be mixed and diluted according to the instructions and at least given as an intravenous infusion. 60 minutes (See Dosage and Administration.)
Cliché I.V. Local reactions have been reported with intravenous azithromycin. The frequency and severity of these adverse reactions were similar when 500 mg azithromycin was administered over 1 hour (2 mg/ml as a 250 ml infusion) or over 3 hours (1 mg/ml infusion). (See ADVERSE REACTIONS.) All volunteers receiving infusion concentrations above 2 mg/ml had local I.V. Local reactions and therefore higher concentrations should be avoided.
, have been seen in treatment with other macrolides. A similar effect of azithromycin in patients at increased risk of chronic cardiac repolarization cannot be completely excluded.
Which Patients With Respiratory Disease Need Long Term Azithromycin?
Increased symptoms of myasthenia gravis and new myositis syndrome have been reported in patients treated with azithromycin.
Prescribing azithromycin without a proven or strong indication for bacterial infection or prophylaxis is unlikely to benefit the patient and increases the risk of developing drug-resistant bacteria.
Patients should be advised to discontinue azithromycin treatment and contact a physician if any allergic reaction occurs.
Patients should be advised that antibiotics, including azithromycin, should only be used to treat bacterial infections. They do not treat viral infections (such as the common cold). When azithromycin is prescribed to treat a bacterial infection, patients should be advised that although it is common to feel better at the beginning of treatment, the medication should be taken as prescribed. Skipping doses or not completing the entire course of treatment can reduce the effectiveness of immediate treatment and increase the chance that bacteria will develop resistance and be treated with azithromycin or other antibiotics in the future.
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Diarrhea is a common problem caused by antibiotics that usually stops when the antibiotic is stopped. Sometimes, after starting antibiotic treatment, patients may have watery, bloody stools (without stomach cramps and fever), even two months or more after the last dose of antibiotic. If this happens, patients should contact a doctor. as soon as possible
In clinical trials of intravenous azithromycin for community-acquired pneumonia, where 2 to 5 I.V. doses were administered, most reported side effects were of mild or moderate severity and resolved when the drug was discontinued. Most of the patients in these studies had one or more comorbidities and received medication at the same time. Approximately 1.2% of patients discontinued IV azithromycin, and a total of 2.4% discontinued IV or oral azithromycin due to clinical or laboratory adverse events.
In clinical trials in patients with pelvic inflammatory disease, where 1 and 2 I.V. doses were administered, 2% of women receiving azithromycin and metronidazole monotherapy discontinued treatment due to clinical adverse events.
Adverse clinical events leading to treatment discontinuation were the most common in these studies
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